Human CD257/BAFF/TNFSF13B protein (Recombinant) (N-Fc) (STJP006718)

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STJP006718
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD257/BAFF/TNFSF13B-N-Fc protein was developed from mammalian cells and has a target region of N-Fc. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TNFSF13B
Gene ID: 10673
Uniprot ID: TN13B_HUMAN
Immunogen Region: Ala134-Leu285
Immunogen: Homo sapiens (Human)
Post Translational Modifications The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. N-glycosylated.
Function Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.
Protein Name Tumor Necrosis Factor Ligand Superfamily Member 13b
B Lymphocyte Stimulator
Blys
B-Cell-Activating Factor
Baff
Dendritic Cell-Derived Tnf-Like Molecule
Tnf- And Apol-Related Leukocyte Expressed Ligand 1
Tall-1
Cd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form
Database Links Reactome: R-HSA-5668541
Reactome: R-HSA-5669034
Reactome: R-HSA-5676594
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Tumor Necrosis Factor Ligand Superfamily Member 13b
Soluble Form: Secreted
Alternative Protein Names Tumor Necrosis Factor Ligand Superfamily Member 13b protein
B Lymphocyte Stimulator protein
Blys protein
B-Cell-Activating Factor protein
Baff protein
Dendritic Cell-Derived Tnf-Like Molecule protein
Tnf- And Apol-Related Leukocyte Expressed Ligand 1 protein
Tall-1 protein
Cd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form protein
TNFSF13B protein
BAFF protein
BLYS protein
TALL1 protein
TNFSF20 protein
ZTNF4 protein
UNQ401 protein
PRO738 protein

Information sourced from Uniprot.org

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