• Human CCL20 (CCL20) Sandwich ELISA Kit (STJE0000099)

Human CCL20 (CCL20) Sandwich ELISA Kit (STJE0000099)

SKU:
STJE0000099-96

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 3.4 pg/mL
Detection Limit: 78-500 pg/ml
Short Description: This CCL20 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Conjugation: Biotin
Storage Instruction: Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time: 4 hours
Detection: Colorimetric
Gene Symbol: CCL20
Gene ID: 6364
Uniprot ID: CCL20_HUMAN
Sample Type: serum, plasma and cell culture supernates
Tissue Specificity Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.
Post Translational Modifications C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
Function Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213.
Protein Name C-C Motif Chemokine 20
Beta-Chemokine Exodus-1
Cc Chemokine Larc
Liver And Activation-Regulated Chemokine
Macrophage Inflammatory Protein 3 Alpha
Mip-3-Alpha
Small-Inducible Cytokine A20 Cleaved Into - Ccl20(1-67 - Ccl20(1-64 - Ccl20(2-70
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-418594
Reactome: R-HSA-6783783
Cellular Localisation Secreted
Alternative ELISA Names C-C Motif Chemokine 20 ELISA kit
Beta-Chemokine Exodus-1 ELISA kit
Cc Chemokine Larc ELISA kit
Liver And Activation-Regulated Chemokine ELISA kit
Macrophage Inflammatory Protein 3 Alpha ELISA kit
Mip-3-Alpha ELISA kit
Small-Inducible Cytokine A20 Cleaved Into - Ccl20(1-67 - Ccl20(1-64 - Ccl20(2-70 ELISA kit
CCL20 ELISA kit
LARC ELISA kit
MIP3A ELISA kit
SCYA20 ELISA kit
output

Information sourced from Uniprot.org

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