| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.054ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This CASP5 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates, cell culture supernates or other biological fluids.. |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
CASP5 |
| Gene ID: |
838 |
| Uniprot ID: |
CASP5_HUMAN |
| Sample Type: |
tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle. |
| Post Translational Modifications | The two subunits are derived from the precursor sequence by an autocatalytic mechanism. |
| Function | Thiol protease that acts as a mediator of programmed cell death. Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. Also mediates cleavage and maturation of IL18. Cleavage of GSDMD and IL18 is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4. During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation. |
| Protein Name | Caspase-5Casp-5Ice(Rel-IiiProtease Ich-3Protease Ty Cleaved Into - Caspase-5 Subunit P20 - Caspase-5 Subunit P10 |
| Database Links | Reactome: R-HSA-5620971 |
| Cellular Localisation | |
| Alternative ELISA Names | Caspase-5 ELISA kitCasp-5 ELISA kitIce(Rel-Iii ELISA kitProtease Ich-3 ELISA kitProtease Ty Cleaved Into - Caspase-5 Subunit P20 - Caspase-5 Subunit P10 ELISA kitCASP5 ELISA kitICH3 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
