• Human CASP5 (Caspase 5) Sandwich ELISA Kit Ready-To-Use (STJE0014070)

Human CASP5 (Caspase 5) Sandwich ELISA Kit Ready-To-Use (STJE0014070)

SKU:
STJE0014070

£443.50 - £605.50
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.054ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This CASP5 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: CASP5
Gene ID: 838
Uniprot ID: CASP5_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle.
Post Translational Modifications The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
Function Thiol protease that acts as a mediator of programmed cell death. Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation.
Protein Name Caspase-5
Casp-5
Ice(Rel-Iii
Protease Ich-3
Protease Ty Cleaved Into - Caspase-5 Subunit P20 - Caspase-5 Subunit P10
Database Links Reactome: R-HSA-5620971
Cellular Localisation
Alternative ELISA Names Caspase-5 ELISA kit
Casp-5 ELISA kit
Ice(Rel-Iii ELISA kit
Protease Ich-3 ELISA kit
Protease Ty Cleaved Into - Caspase-5 Subunit P20 - Caspase-5 Subunit P10 ELISA kit
CASP5 ELISA kit
ICH3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance