| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.114ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This CAMKK2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
CAMKK2 |
| Gene ID: |
10645 |
| Uniprot ID: |
KKCC2_HUMAN |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung. |
| Post Translational Modifications | Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation. |
| Function | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals. Seems to be involved in hippocampal activation of CREB1. May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. |
| Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Kinase 2Cam-Kk 2Cam-Kinase Kinase 2Camkk 2Calcium/Calmodulin-Dependent Protein Kinase Kinase BetaCam-Kk BetaCam-Kinase Kinase BetaCamkk Beta |
| Database Links | Reactome: R-HSA-111932Reactome: R-HSA-442729Reactome: R-HSA-9619229Reactome: R-HSA-9619483 |
| Cellular Localisation | NucleusCytoplasmCell ProjectionNeuron ProjectionPredominantly Nuclear In Unstimulated CellsRelocalizes Into Cytoplasm And Neurites After Forskolin Induction |
| Alternative ELISA Names | Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 ELISA kitCam-Kk 2 ELISA kitCam-Kinase Kinase 2 ELISA kitCamkk 2 ELISA kitCalcium/Calmodulin-Dependent Protein Kinase Kinase Beta ELISA kitCam-Kk Beta ELISA kitCam-Kinase Kinase Beta ELISA kitCamkk Beta ELISA kitCAMKK2 ELISA kitCAMKKB ELISA kitKIAA0787 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
