| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.063ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This CADM1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
CADM1 |
| Gene ID: |
23705 |
| Uniprot ID: |
CADM1_HUMAN |
| Sample Type: |
serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | Glycosylation at Asn-67 and Asn-101 promotes adhesive binding and synapse induction. |
| Function | Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node. Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells. Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. May contribute to the less invasive phenotypes of lepidic growth tumor cells. |
| Protein Name | Cell Adhesion Molecule 1Immunoglobulin Superfamily Member 4Igsf4Nectin-Like Protein 2Necl-2Spermatogenic Immunoglobulin SuperfamilySgigsfSynaptic Cell Adhesion MoleculeSyncamTumor Suppressor In Lung Cancer 1Tslc-1 |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSynapseLocalized To The Basolateral Plasma Membrane Of Epithelial Cells In Gall Bladder |
| Alternative ELISA Names | Cell Adhesion Molecule 1 ELISA kitImmunoglobulin Superfamily Member 4 ELISA kitIgsf4 ELISA kitNectin-Like Protein 2 ELISA kitNecl-2 ELISA kitSpermatogenic Immunoglobulin Superfamily ELISA kitSgigsf ELISA kitSynaptic Cell Adhesion Molecule ELISA kitSyncam ELISA kitTumor Suppressor In Lung Cancer 1 ELISA kitTslc-1 ELISA kitCADM1 ELISA kitIGSF4 ELISA kitIGSF4A ELISA kitNECL2 ELISA kitSYNCAM ELISA kitTSLC1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
