Human BMPR-1A/ALK-3 protein (Recombinant) (C-hFc&His) (STJP000931)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenActive Recombinant Human BMPR-1A/ALK-3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Arg152) of human BMPRIA/ALK-3/CD292 (Accession #NP_004320.2) fused with an Fc, 6×His tag at the C-term
General Information
| Short Description | Recombinant-Human BMPR-1A/ALK-3-C-hFc&His protein was developed in hek293 cells using the region Gln24-Arg152. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized Human ACVR2B at 1 Mu g/mL (100 Mu L/well) can bind Human BMPRIA with a linear range of 0.5-62.5 ng/mL. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | BMPR1A |
| Gene ID | 657 |
| Uniprot ID | BMR1A_HUMAN |
| Immunogen | Active Recombinant Human BMPR-1A/ALK-3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Arg152) of human BMPRIA/ALK-3/CD292 (Accession #NP_004320.2) fused with an Fc, 6×His tag at the C-term |
| Immunogen Region | Gln24-Arg152 |
| Immunogen Sequence | QNLDSMLHGTGMKSDSDQKK SENGVTLAPEDTLPFLKCYC SGHCPDDAINNTCITNGHCF AIIEEDDQGETTLASGCMKY EGSDFQCKDSPKAQLRRTIE CCRTNLCNQYLQPTLPPVVI GPFFDGSIR |
Additional Info
| Tissue Specificity | Highly expressed in skeletal muscle. |
| Post Translational Modifications | Glycosylated. |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2. |
| Protein Name | Bone Morphogenetic Protein Receptor Type-1aBmp Type-1a ReceptorBmpr-1aActivin Receptor-Like Kinase 3Alk-3Serine/Threonine-Protein Kinase Receptor R5Skr5Cd Antigen Cd292 |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell Surface |
| Alternative Protein Names | Bone Morphogenetic Protein Receptor Type-1a proteinBmp Type-1a Receptor proteinBmpr-1a proteinActivin Receptor-Like Kinase 3 proteinAlk-3 proteinSerine/Threonine-Protein Kinase Receptor R5 proteinSkr5 proteinCd Antigen Cd292 proteinBMPR1A proteinACVRLK3 proteinALK3 protein |
Information sourced from Uniprot.org