Name: Human BMPR-1A/ALK-3 protein (Recombinant) (C-hFc&His) (STJP000931)
SKU: STJP000931
Availability: InStock

Human BMPR-1A/ALK-3 protein (Recombinant) (C-hFc&His) (STJP000931)

SKU:

STJP000931

£64.50 - £224.50

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	< 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Human ACVR2B at 1 Mu g/mL (100 Mu L/well) can bind Human BMPRIA with a linear range of 0.5-62.5 ng/mL.

Gene Symbol:	BMPR1A
Gene ID:	657
Uniprot ID:	BMR1A_HUMAN
Immunogen:	Active Recombinant Human BMPR-1A/ALK-3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Arg152) of human BMPRIA/ALK-3/CD292 (Accession #NP_004320.2) fused with an Fc, 6×His tag at the C-term
Immunogen Sequence:	QNLDSMLHGTGMKSDSDQKK SENGVTLAPEDTLPFLKCYC SGHCPDDAINNTCITNGHCF AIIEEDDQGETTLASGCMKY EGSDFQCKDSPKAQLRRTIE CCRTNLCNQYLQPTLPPVVI GPFFDGSIR

Tissue Specificity	Highly expressed in skeletal muscle.
Post Translational Modifications	Glycosylated.
Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2.
Protein Name	Bone Morphogenetic Protein Receptor Type-1a Bmp Type-1a Receptor Bmpr-1a Activin Receptor-Like Kinase 3 Alk-3 Serine/Threonine-Protein Kinase Receptor R5 Skr5 Cd Antigen Cd292
Database Links	Reactome: R-HSA-201451
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Cell Surface
Alternative Protein Names	Bone Morphogenetic Protein Receptor Type-1a protein Bmp Type-1a Receptor protein Bmpr-1a protein Activin Receptor-Like Kinase 3 protein Alk-3 protein Serine/Threonine-Protein Kinase Receptor R5 protein Skr5 protein Cd Antigen Cd292 protein BMPR1A protein ACVRLK3 protein ALK3 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP001235	Human BMPR-1B/ALK-6 protein (Recombinant) (C-hFc&His) (STJP001235)	HEK293 cells
STJP001413	Human BMPR-2 protein (Recombinant) (C-hFc) (STJP001413)	HEK293 cells
STJP001023	Human ALK-7/ACVR1C protein (Recombinant) (C-hFc&His) (STJP001023)	HEK293 cells
STJP002553	Human ALK-4/ACVR1B protein (Recombinant) (C-hFc & his) (STJP002553)	HEK293 cells
STJP002758	Human TGFR-1/ALK-5 protein (Recombinant) (C-hFc & His) (STJP002758)	HEK293 cells
STJP001410	Human BMPR-2 protein (Recombinant) (C-His) (STJP001410)	HEK293 cells
STJP000934	Human Siglec-3/CD33 protein (Recombinant) (C-hFc&His) (STJP000934)	HEK293 cells
STJP001079	Human ICAM-3/CD50 protein (Recombinant) (C-hFc&His) (STJP001079)	HEK293 cells
STJP000919	Human FGFR-3/CD333 protein (Recombinant) (C-hFc&His) (STJP000919)	HEK293 cells

Human BMPR-1A/ALK-3 protein (Recombinant) (C-hFc&His) (STJP000931)