Human AXIN2 protein (Recombinant) (N-His) (STJP006250)

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STJP006250
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AXIN2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: AXIN2
Gene ID: 8313
Uniprot ID: AXIN2_HUMAN
Immunogen Region: Pro350-Lys631
Immunogen: Homo sapiens (Human)
Post Translational Modifications Probably phosphorylated by GSK3B and dephosphorylated by PP2A. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.
Function Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Protein Name Axin-2
Axin-Like Protein
Axil
Axis Inhibition Protein 2
Conductin
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-4411364
Reactome: R-HSA-4641257
Reactome: R-HSA-5689880
Cellular Localisation Cytoplasm
Alternative Protein Names Axin-2 protein
Axin-Like Protein protein
Axil protein
Axis Inhibition Protein 2 protein
Conductin protein
AXIN2 protein

Information sourced from Uniprot.org

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