| Host: |
Mammalian |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human Asparaginyl endopeptidase/Legumain-C-His protein was developed from mammalian and has a target region of C-His. For use in research applications. |
| Formulation: |
Supplied as a 0.2 Mu m filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 10% Glycerol, pH 8.0. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LGMN |
| Gene ID: |
5641 |
| Uniprot ID: |
LGMN_HUMAN |
| Immunogen Region: |
Ile18-Tyr433 |
| Immunogen: |
Recombinant Human Asparaginyl endopeptidase/Legumain Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Ile18-Tyr433) of human Legumain (Accession #AAH03061.1) fused with His tag at the C-terminus. |
| Post Translational Modifications | Activated by autocatalytic processing at pH 4. |
| Function | Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. |
| Protein Name | LegumainAsparaginyl EndopeptidaseAepProtease - Cysteine 1 |
| Database Links | Reactome: R-HSA-1679131Reactome: R-HSA-196791Reactome: R-HSA-2132295 |
| Cellular Localisation | Lysosome |
| Alternative Protein Names | Legumain proteinAsparaginyl Endopeptidase proteinAep proteinProtease - Cysteine 1 proteinLGMN proteinPRSC1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
