| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription. |
| Protein Name | Aryl Hydrocarbon Receptor Nuclear TranslocatorArnt ProteinClass E Basic Helix-Loop-Helix Protein 2Bhlhe2Dioxin Receptor - Nuclear TranslocatorHypoxia-Inducible Factor 1-BetaHif-1-BetaHif1-Beta |
| Database Links | Reactome: R-HSA-1234158Reactome: R-HSA-1989781Reactome: R-HSA-211945Reactome: R-HSA-211976Reactome: R-HSA-211981Reactome: R-HSA-8937144Reactome: R-HSA-9768919 |
| Cellular Localisation | Nucleus |
| Alternative ELISA Names | Aryl Hydrocarbon Receptor Nuclear Translocator ELISA kitArnt Protein ELISA kitClass E Basic Helix-Loop-Helix Protein 2 ELISA kitBhlhe2 ELISA kitDioxin Receptor - Nuclear Translocator ELISA kitHypoxia-Inducible Factor 1-Beta ELISA kitHif-1-Beta ELISA kitHif1-Beta ELISA kitARNT ELISA kitBHLHE2 ELISA kit |
| output | |
Information sourced from Uniprot.org
