• Human ARHGEF7 (Rho Guanine Nucleotide Exchange Factor 7) Sandwich ELISA Kit Ready-To-Use (STJE0013684)

Human ARHGEF7 (Rho Guanine Nucleotide Exchange Factor 7) Sandwich ELISA Kit Ready-To-Use (STJE0013684)

SKU:
STJE0013684

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 29.4pg/mL
Detection Limit: 78.1-5000pg/mL
Short Description: This ARHGEF7 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: ARHGEF7
Gene ID: 8874
Uniprot ID: ARHG7_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylated by PTK2/FAK1.this promotes interaction with RAC1. Phosphorylated on Ser-694 by CaMK1.enhancement of GEF activity and downstream activation of RAC1.
Function Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
Protein Name Rho Guanine Nucleotide Exchange Factor 7
Beta-Pix
Cool-1
Pak-Interacting Exchange Factor Beta
P85
Database Links Reactome: R-HSA-182971
Reactome: R-HSA-193648
Reactome: R-HSA-3928664
Reactome: R-HSA-416482
Reactome: R-HSA-8980692
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013406
Reactome: R-HSA-9013409
Reactome: R-HSA-9013420
Reactome: R-HSA-9013424
Reactome: R-HSA-9619229 Q14155-1
Cellular Localisation Cell Junction
Focal Adhesion
Cell Projection
Ruffle
Cytoplasm
Cell Cortex
Lamellipodium
Detected At Cell Adhesions
A Small Proportion Is Detected At Focal Adhesions
Alternative ELISA Names Rho Guanine Nucleotide Exchange Factor 7 ELISA kit
Beta-Pix ELISA kit
Cool-1 ELISA kit
Pak-Interacting Exchange Factor Beta ELISA kit
P85 ELISA kit
ARHGEF7 ELISA kit
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KIAA0142 ELISA kit
P85SPR ELISA kit
PAK3BP ELISA kit
PIXB ELISA kit
Nbla10314 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance