| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.073ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This APOO Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
APOO |
| Gene ID: |
79135 |
| Uniprot ID: |
MIC26_HUMAN |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed in all tissues examined. Up-regulated in diabetic heart. |
| Post Translational Modifications | O-glycosylation.glycosaminoglycan of chondroitin-sulfate type. |
| Function | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function. Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts. Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. |
| Protein Name | Micos Complex Subunit Mic26Apolipoprotein OMicos Complex Subunit Mic23Protein Fam121b |
| Database Links | Reactome: R-HSA-8949613 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane ProteinSecretedMitochondrionGolgi Apparatus MembraneEndoplasmic Reticulum MembraneExists In Three Distinct Forms: A Glycosylated And Secreted FormAn Er/Golgi-Resident Form And A Non-Glycosylated Mitochondrial Form |
| Alternative ELISA Names | Micos Complex Subunit Mic26 ELISA kitApolipoprotein O ELISA kitMicos Complex Subunit Mic23 ELISA kitProtein Fam121b ELISA kitAPOO ELISA kitFAM121B ELISA kitMIC23 ELISA kitMIC26 ELISA kitMy025 ELISA kitUNQ1866 ELISA kitPRO4302 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
