• Human ANLN (Anillin) Sandwich ELISA Kit (STJE0007162)

Human ANLN (Anillin) Sandwich ELISA Kit (STJE0007162)

SKU:
STJE0007162

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 14.1pg/mL
Detection Limit: 31.2-2000pg/mL
Short Description: This ANLN Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: ANLN
Gene ID: 54443
Uniprot ID: ANLN_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus. Expression is significantly increased in renal biopsy specimens from idiopathic FSGS. Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.
Post Translational Modifications Phosphorylated during mitosis. Ubiquitinated, and this requires FZR1/CDH1.
Function Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration.
Protein Name Anillin
Database Links Reactome: R-HSA-8980692
Reactome: R-HSA-9013026
Reactome: R-HSA-9013106
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Cell Cortex
Cell Projection
Bleb
Mainly Found In The Nucleus During Interphase
Colocalizes With Cortical F-Actin Upon Nuclear Envelope Breakdown In Mitosis And Subsequently Concentrates In The Area Of The Prospective Contractile Ring In Anaphase
This Pattern Persists Until Telophase
When The Protein Becomes Concentrated In The Midbody
Alternative ELISA Names Anillin ELISA kit
ANLN ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance