• Human ADAMTS1 (A Disintegrin And Metalloproteinase With Thrombospondin 1) Sandwich ELISA Kit Ready-To-Use (STJE0013275)

Human ADAMTS1 (A Disintegrin And Metalloproteinase With Thrombospondin 1) Sandwich ELISA Kit Ready-To-Use (STJE0013275)

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STJE0013275

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.27ng/mL
Detection Limit: 0.781-50ng/mL
Short Description: This ADAMTS1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: ADAMTS1
Gene ID: 9510
Uniprot ID: ATS1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion.
Function Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
Protein Name A Disintegrin And Metalloproteinase With Thrombospondin Motifs 1
Adam-Ts 1
Adam-Ts1
Adamts-1
Meth-1
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-5083635
Reactome: R-HSA-5173214
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative ELISA Names A Disintegrin And Metalloproteinase With Thrombospondin Motifs 1 ELISA kit
Adam-Ts 1 ELISA kit
Adam-Ts1 ELISA kit
Adamts-1 ELISA kit
Meth-1 ELISA kit
ADAMTS1 ELISA kit
KIAA1346 ELISA kit
METH1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance