Applications: |
ELISA |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Sensitivity: |
0.063ng/mL |
Detection Limit: |
0.156-10ng/mL |
Short Description: |
This ACVR1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
Assay Time: |
3 hrs |
Gene Symbol: |
ACVR1 |
Gene ID: |
90 |
Uniprot ID: |
ACVR1_HUMAN |
Immunogen Region: |
Ready-To-Use |
Sample Type: |
tissue homogenates or other biological fluids. |
Tissue Specificity | Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. |
Post Translational Modifications | |
Function | Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B. Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor. Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs. May promote the expression of HAMP, potentially via its interaction with BMP6. |
Protein Name | Activin Receptor Type-1Activin Receptor Type IActr-IActivin Receptor-Like Kinase 2Alk-2Serine/Threonine-Protein Kinase Receptor R1Skr1Tgf-B Superfamily Receptor Type ITsr-I |
Database Links | |
Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
Alternative ELISA Names | Activin Receptor Type-1 ELISA kitActivin Receptor Type I ELISA kitActr-I ELISA kitActivin Receptor-Like Kinase 2 ELISA kitAlk-2 ELISA kitSerine/Threonine-Protein Kinase Receptor R1 ELISA kitSkr1 ELISA kitTgf-B Superfamily Receptor Type I ELISA kitTsr-I ELISA kitACVR1 ELISA kitACVRLK2 ELISA kit |
output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance