| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human Activin RIIB/ACVR2B-C-hFc & His protein was developed from hek293 cells and has a target region of C-hFc & His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
1.Measured by its binding ability in a functional ELISA.Immobilized Human ACVR2B at 1 Mu g/mL (100 Mu L/well) can bind Human BMPRIA with a linear range of 0.5-62.5 ng/mL.2.Measured by its binding ability in a functional ELISA.Immobilized Human CD105 |
| Gene Symbol: |
ACVR2B |
| Gene ID: |
93 |
| Uniprot ID: |
AVR2B_HUMAN |
| Immunogen Region: |
Ser19-Thr134 |
| Immunogen: |
Recombinant Human Activin RIIB/ACVR2B Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser19-Thr134) of human ACVR2B/Activin RIIB (Accession #NP_001097.2) fused with an Fc, 6×His tag at the C-termi |
| Function | Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. |
| Protein Name | Activin Receptor Type-2bActivin Receptor Type IibActr-Iib |
| Database Links | Reactome: R-HSA-1181150Reactome: R-HSA-1433617Reactome: R-HSA-1502540Reactome: R-HSA-201451 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Activin Receptor Type-2b proteinActivin Receptor Type Iib proteinActr-Iib proteinACVR2B protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
