Function | Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs). |
Protein Name | Long-Chain-Fatty-Acid--Coa Ligase 1Acyl-Coa Synthetase 1Acs1Arachidonate--Coa LigaseLong-Chain Acyl-Coa Synthetase 1Lacs 1Long-Chain Acyl-Coa Synthetase 2Lacs 2Long-Chain Fatty Acid-Coa Ligase 2Palmitoyl-Coa Ligase 1Palmitoyl-Coa Ligase 2Phytanate--Coa Ligase |
Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2046105Reactome: R-HSA-2046106Reactome: R-HSA-75876 |
Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Type Iii Membrane ProteinPeroxisome MembraneMicrosome MembraneEndoplasmic Reticulum Membrane |
Alternative Protein Names | Long-Chain-Fatty-Acid--Coa Ligase 1 proteinAcyl-Coa Synthetase 1 proteinAcs1 proteinArachidonate--Coa Ligase proteinLong-Chain Acyl-Coa Synthetase 1 proteinLacs 1 proteinLong-Chain Acyl-Coa Synthetase 2 proteinLacs 2 proteinLong-Chain Fatty Acid-Coa Ligase 2 proteinPalmitoyl-Coa Ligase 1 proteinPalmitoyl-Coa Ligase 2 proteinPhytanate--Coa Ligase proteinACSL1 proteinFACL1 proteinFACL2 proteinLACS proteinLACS1 proteinLACS2 protein |
Information sourced from Uniprot.org