| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
1.09ng/mL |
| Detection Limit: |
3.12-200ng/mL |
| Short Description: |
This ACACa Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
ACACA |
| Gene ID: |
31 |
| Uniprot ID: |
ACACA_HUMAN |
| Sample Type: |
serum, plasma or other biological fluids. |
| Tissue Specificity | Expressed in brain, placenta, skeletal muscle, renal, pancreatic and adipose tissues.expressed at low level in pulmonary tissue.not detected in the liver. |
| Post Translational Modifications | Phosphorylation on Ser-1263 is required for interaction with BRCA1. Phosphorylation at Ser-80 by AMPK inactivates enzyme activity. The biotin cofactor is covalently attached to the central biotinyl-binding domain and is required for the catalytic activity. |
| Function | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. |
| Protein Name | Acetyl-Coa Carboxylase 1Acc1Acetyl-Coenzyme A Carboxylase AlphaAcc-Alpha |
| Database Links | Reactome: R-HSA-163765Reactome: R-HSA-196780Reactome: R-HSA-200425Reactome: R-HSA-2426168Reactome: R-HSA-3371599Reactome: R-HSA-75105 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative ELISA Names | Acetyl-Coa Carboxylase 1 ELISA kitAcc1 ELISA kitAcetyl-Coenzyme A Carboxylase Alpha ELISA kitAcc-Alpha ELISA kitACACA ELISA kitACAC ELISA kitACC1 ELISA kitACCA ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
