• Human ABI1 (Abl Interactor 1) Sandwich ELISA Kit (STJE0006831)

Human ABI1 (Abl Interactor 1) Sandwich ELISA Kit (STJE0006831)

SKU:
STJE0006831

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.055ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This ABI1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: ABI1
Gene ID: 10006
Uniprot ID: ABI1_HUMAN
Sample Type: serum, plasma or other biological fluids.
Tissue Specificity Widely expressed, with highest expression in brain.
Post Translational Modifications Phosphorylated on tyrosine residues after serum stimulation or induction by v-Abl. Seems to be phosphorylated at Tyr-53 by ABL1, required for nuclear but not for synaptic localization.
Function May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
Protein Name Abl Interactor 1
Abelson Interactor 1
Abi-1
Abl-Binding Protein 4
Ablbp4
Eps8 Sh3 Domain-Binding Protein
Eps8-Binding Protein
Nap1-Binding Protein
Nap1bp
Spectrin Sh3 Domain-Binding Protein 1
E3b1
Database Links Reactome: R-HSA-2029482
Reactome: R-HSA-4420097
Reactome: R-HSA-5663213
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013423
Reactome: R-HSA-9664422
Cellular Localisation Cytoplasm
Nucleus
Cell Projection
Lamellipodium
Filopodium
Growth Cone
Postsynaptic Density
Cytoskeleton
Localized To Protruding Lamellipodia And Filopodia Tips
Also Localized To Neuronal Growth Cones And Synaptosomes
May Shuttle From The Postsynaptic Densities To The Nucleus
Alternative ELISA Names Abl Interactor 1 ELISA kit
Abelson Interactor 1 ELISA kit
Abi-1 ELISA kit
Abl-Binding Protein 4 ELISA kit
Ablbp4 ELISA kit
Eps8 Sh3 Domain-Binding Protein ELISA kit
Eps8-Binding Protein ELISA kit
Nap1-Binding Protein ELISA kit
Nap1bp ELISA kit
Spectrin Sh3 Domain-Binding Protein 1 ELISA kit
E3b1 ELISA kit
ABI1 ELISA kit
SSH3BP1 ELISA kit
output

Information sourced from Uniprot.org

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