| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.126ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This ABCC6 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
ABCC6 |
| Gene ID: |
368 |
| Uniprot ID: |
MRP6_HUMAN |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Expressed in kidney and liver. Very low expression in other tissues. In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells and moderately in the adluminal compartment of the seminiferous tubules. |
| Post Translational Modifications | Glycosylated. |
| Function | Isoform 1: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin. Isoform 1: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 6Anthracycline Resistance-Associated ProteinMulti-Specific Organic Anion Transporter EMoat-EMultidrug Resistance-Associated Protein 6 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-5690338 |
| Cellular Localisation | Basal Cell MembraneMulti-Pass Membrane ProteinLocalized To The Basal Membrane Of Sertoli CellsIsoform 1: Basolateral Cell MembraneIsoform 2: Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative ELISA Names | Atp-Binding Cassette Sub-Family C Member 6 ELISA kitAnthracycline Resistance-Associated Protein ELISA kitMulti-Specific Organic Anion Transporter E ELISA kitMoat-E ELISA kitMultidrug Resistance-Associated Protein 6 ELISA kitABCC6 ELISA kitARA ELISA kitMRP6 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
