• Human ABCC4 (ATP Binding Cassette Transporter C4) Sandwich ELISA Kit Ready-To-Use (STJE0013198)

Human ABCC4 (ATP Binding Cassette Transporter C4) Sandwich ELISA Kit Ready-To-Use (STJE0013198)

SKU:
STJE0013198

£481.50 - £659.50
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.118ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This ABCC4 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: ABCC4
Gene ID: 10257
Uniprot ID: MRP4_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. sinusoidal membrane of hepatocytes.
Post Translational Modifications N-glycosylated.leading to substrate-selective effects on its transport activity.
Function ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Confers resistance to anticancer agents such as methotrexate.
Protein Name Atp-Binding Cassette Sub-Family C Member 4
Mrp/Cmoat-Related Abc Transporter
Multi-Specific Organic Anion Transporter B
Moat-B
Multidrug Resistance-Associated Protein 4
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-382556
Reactome: R-HSA-9748787
Reactome: R-HSA-9753281
Cellular Localisation Basolateral Cell Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Its Localization To The Basolateral Or Apical Membranes Is Tissue-Dependent
Alternative ELISA Names Atp-Binding Cassette Sub-Family C Member 4 ELISA kit
Mrp/Cmoat-Related Abc Transporter ELISA kit
Multi-Specific Organic Anion Transporter B ELISA kit
Moat-B ELISA kit
Multidrug Resistance-Associated Protein 4 ELISA kit
ABCC4 ELISA kit
MOATB ELISA kit
MRP4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance