• Human ABCC3 (ATP Binding Cassette Transporter C3) Sandwich ELISA Kit Ready-To-Use (STJE0013197)

Human ABCC3 (ATP Binding Cassette Transporter C3) Sandwich ELISA Kit Ready-To-Use (STJE0013197)

SKU:
STJE0013197

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.105ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This ABCC3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: ABCC3
Gene ID: 8714
Uniprot ID: MRP3_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney. In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells and moderately in the adluminal compartment of the seminiferous tubules.
Post Translational Modifications
Function ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells.
Protein Name Atp-Binding Cassette Sub-Family C Member 3
Canalicular Multispecific Organic Anion Transporter 2
Multi-Specific Organic Anion Transporter D
Moat-D
Multidrug Resistance-Associated Protein 3
Database Links Reactome: R-HSA-159418
Reactome: R-HSA-382556
Reactome: R-HSA-9749641
Reactome: R-HSA-9753281
Cellular Localisation Basolateral Cell Membrane
Multi-Pass Membrane Protein
Basal Cell Membrane
Localized To The Basolateral Membrane Of Enterocytes
Localized To The Basal Membrane Of Sertoli Cells
Alternative ELISA Names Atp-Binding Cassette Sub-Family C Member 3 ELISA kit
Canalicular Multispecific Organic Anion Transporter 2 ELISA kit
Multi-Specific Organic Anion Transporter D ELISA kit
Moat-D ELISA kit
Multidrug Resistance-Associated Protein 3 ELISA kit
ABCC3 ELISA kit
CMOAT2 ELISA kit
MLP2 ELISA kit
MRP3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance