• Human ABCA4 (ATP Binding Cassette Transporter A4) Sandwich ELISA Kit (STJE0006815)

Human ABCA4 (ATP Binding Cassette Transporter A4) Sandwich ELISA Kit (STJE0006815)

SKU:
STJE0006815

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.112ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This ABCA4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: ABCA4
Gene ID: 24
Uniprot ID: ABCA4_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Retinal-specific. Seems to be exclusively found in the rims of rod photoreceptor cells.
Post Translational Modifications Proteolytic cleavage by trypsin leads to a 120-kDa N-terminal fragment and a 115-kDa C-terminal fragment that are linked through disulfide bonds. N-glycosylated. Phosphorylation is independent of light exposure and modulates ATPase activity.
Function Flippase that catalyzes in an ATP-dependent manner the transport of retinal-phosphatidylethanolamine conjugates like the 11-cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine from the lumen to the cytoplasmic leaflet of photoreceptor outer segment disk membranes, where N-cis-retinylidene-phosphatidylethanolamine (N-cis-R-PE) is then isomerized to its all-trans isomer (N-trans-R-PE) and reduced by RDH8 to produce all-trans-retinol (all-trans-rol) and therefore prevents the accumulation of excess of 11-cis-retinal and its schiff-base conjugate and the formation of toxic bisretinoid. May display both ATPase and GTPase activity that is strongly influenced by the lipid environment and the presence of retinoid compounds. Binds the unprotonated form of N-retinylidene-phosphatidylethanolamine with high affinity in the absence of ATP, and ATP binding and hydrolysis induce a protein conformational change that causes the dissociation of N-retinylidene-phosphatidylethanolamine.
Protein Name Retinal-Specific Phospholipid-Transporting Atpase Abca4
Atp-Binding Cassette Sub-Family A Member 4
Rim Abc Transporter
Rim Proteinv
Rmp
Retinal-Specific Atp-Binding Cassette Transporter
Stargardt Disease Protein
Database Links Reactome: R-HSA-2453864
Reactome: R-HSA-2453902
Reactome: R-HSA-382556
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum
Cytoplasmic Vesicle
Cell Projection
Cilium
Photoreceptor Outer Segment
Localized To The Rim And Incisures Of Rod Outer Segments Disks
Alternative ELISA Names Retinal-Specific Phospholipid-Transporting Atpase Abca4 ELISA kit
Atp-Binding Cassette Sub-Family A Member 4 ELISA kit
Rim Abc Transporter ELISA kit
Rim Proteinv ELISA kit
Rmp ELISA kit
Retinal-Specific Atp-Binding Cassette Transporter ELISA kit
Stargardt Disease Protein ELISA kit
ABCA4 ELISA kit
ABCR ELISA kit
output

Information sourced from Uniprot.org

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