| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Glucose Transporter GLUT4 Blocking Peptide is synthetically produced from the 450-509 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Slc2a4 |
| Gene ID: |
20528 |
| Uniprot ID: |
GLUT4_MOUSE |
| Immunogen Region: |
450-509 |
| Immunogen: |
Synthetic peptide taken within amino acid region 450-509 on mouse Solute carrier family 2, facilitated glucose transporter member 4 protein. |
| Tissue Specificity | Expressed in skeletal and cardiac muscles. Expressed in brown and white adipose tissues. |
| Post Translational Modifications | Sumoylated. Palmitoylated. Palmitoylation by ZDHHC7 controls the insulin-dependent translocation of GLUT4 to the plasma membrane. |
| Function | Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. |
| Peptide Name | Solute Carrier Family 2 - Facilitated Glucose Transporter Member 4Gt2Glucose Transporter Type 4 - Insulin-ResponsiveGlut-4 |
| Database Links | Reactome: R-MMU-189200 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndomembrane SystemCytoplasmPerinuclear RegionLocalizes Primarily To The Perinuclear RegionUndergoing Continued Recycling To The Plasma Membrane Where It Is Rapidly ReinternalizedThe Dileucine Internalization Motif Is Critical For Intracellular SequestrationInsulin Stimulation Induces Translocation To The Cell Membrane |
| Alternative Peptide Names | Solute Carrier Family 2 - Facilitated Glucose Transporter Member 4 proteinGt2 proteinGlucose Transporter Type 4 - Insulin-Responsive proteinGlut-4 proteinSlc2a4 proteinGlut4 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
