EPAC1 Blocking Peptide peptide (STJ504008)

SKU:
STJ504008-250
£281.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : EPAC1 Blocking Peptide is synthetically produced from the 5-50 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: RAPGEF3
Gene ID: 10411
Uniprot ID: RPGF3_HUMAN
Immunogen Region: 5-50
Immunogen: Synthetic peptide taken within amino acid region 5-50 on Exchange Protein Directly Activated by cAMP protein.
Tissue Specificity Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.
Function Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Peptide Name Rap Guanine Nucleotide Exchange Factor 3
Exchange Factor Directly Activated By Camp 1
Exchange Protein Directly Activated By Camp 1
Epac 1
Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By Camp
Camp-Regulated Guanine Nucleotide Exchange Factor I
Camp-Gefi
Database Links Reactome: R-HSA-354192
Reactome: R-HSA-381676
Reactome: R-HSA-392517
Reactome: R-HSA-422356
Cellular Localisation Endomembrane System
Alternative Peptide Names Rap Guanine Nucleotide Exchange Factor 3 protein
Exchange Factor Directly Activated By Camp 1 protein
Exchange Protein Directly Activated By Camp 1 protein
Epac 1 protein
Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By Camp protein
Camp-Regulated Guanine Nucleotide Exchange Factor I protein
Camp-Gefi protein
RAPGEF3 protein
CGEF1 protein
EPAC protein
EPAC1 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJ504009 EPAC1 Blocking Peptide peptide (STJ504009) Immunodepletion/Immunocompetition
STJ504045 EPAC1 Positive Control peptide (STJ504045) WB
STJ504998 Thickveins Peptide Blocking Peptide peptide (STJ504998) Immunodepletion/Immunocompetition
STJ505378 hCG beta Peptide Blocking Peptide peptide (STJ505378) Immunodepletion/Immunocompetition
STJ505377 hCG beta Peptide Blocking Peptide peptide (STJ505377) Immunodepletion/Immunocompetition
STJ505671 BLK Blocking Peptide peptide (STJ505671) Immunodepletion/Immunocompetition
STJ503963 CRMP3 Blocking Peptide peptide (STJ503963) Immunodepletion/Immunocompetition
STJ503795 CD21 Blocking Peptide peptide (STJ503795) Immunodepletion/Immunocompetition
STJ504002 ELOVL4 Blocking Peptide peptide (STJ504002) Immunodepletion/Immunocompetition
!