| Tissue Specificity | Found almost exclusively in brain and skin. Ubiquitously detected in different brain regions with very prominent expression in lower brain regions such as the midbrain, pons, medulla, and spinal cord. Expressed predominantly within white matter tracts of the brain. Corpus callosum, optic nerve, olfactory tract, anterior commissure, internal and external capsules, fimbra of the hippocampus, mammillary tract, stria medullaris, and white matter of the cerebellum and brain stem all express the receptor. Within the striatum itself white matter fascicles express the receptor. Detected also in spleen and lung. Not observed in heart, liver, skeletal muscle, kidney, or testes. |
| Function | Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/O)alpha and G(12) subclass of heteromeric G-proteins. Displays antiproliferative effects in transfected CHO-K1 and HEK293 cells. |
| Peptide Name | Sphingosine 1-Phosphate Receptor 5S1p Receptor 5S1p5Endothelial Differentiation G-Protein-Coupled Receptor 8Nerve Growth Factor-Regulated G-Protein-Coupled Receptor 1Nrg-1Sphingosine 1-Phosphate Receptor Edg-8S1p Receptor Edg-8 |
| Database Links | Reactome: R-RNO-418594Reactome: -RNO-419408 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | Sphingosine 1-Phosphate Receptor 5 proteinS1p Receptor 5 proteinS1p5 proteinEndothelial Differentiation G-Protein-Coupled Receptor 8 proteinNerve Growth Factor-Regulated G-Protein-Coupled Receptor 1 proteinNrg-1 proteinSphingosine 1-Phosphate Receptor Edg-8 proteinS1p Receptor Edg-8 proteinS1pr5 proteinEdg8 proteinNrg1 protein |
Information sourced from Uniprot.org
