| Tissue Specificity | Ubiquitously expressed during embryogenesis, with higher expression in regions of the central nervous system, dorsal root ganglia, submandibular gland, epidermis and breast. In 12-week-old NOD mice, expression of isoform 2 is sevenfold higher in lymph node stromal elements than in T-cells and tenfold higher than in B-cells. |
| Post Translational Modifications | May be phosphorylated by DNA-PK complex in a DNA independent manner (in vitro). |
| Function | Transcription factor that binds to sequence with multiple copies of 5'-TTCCGG-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 2. Isoform 2 may inhibit transcriptional activity of isoform 1 by interacting with it and retaining it in the cytoplasm. Transcriptional activator of EIF4G3. May also involved in behavior. |
| Peptide Name | Deformed Epidermal Autoregulatory Factor 1 HomologNuclear Deaf-1-Related Transcriptional RegulatorNudr |
| Cellular Localisation | Isoform 1: NucleusCytoplasmIsoform 2: CytoplasmNucleusDisplays Some Nuclear Localization When Expressed With Isoform 1Suggesting That It May Heterodimerize With Isoform 1 And Shuttle To The Nucleus Using The Nuclear Localization Signal Of Isoform 1 |
| Alternative Peptide Names | Deformed Epidermal Autoregulatory Factor 1 Homolog proteinNuclear Deaf-1-Related Transcriptional Regulator proteinNudr proteinDeaf1 protein |
Information sourced from Uniprot.org
