Tissue Specificity | Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. Highly expressed in placenta, lung, skeletal muscle, kidney. |
Post Translational Modifications | N-glycosylated. The N-terminus is blocked. Palmitoylated on Cys-13.which is required for caveola targeting. |
Function | Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides (Probable). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow. |
Peptide Name | Ectonucleoside Triphosphate Diphosphohydrolase 1Atp DiphosphohydrolaseAtp-DphAtpdaseEcto-Atp Diphosphohydrolase 1Ecto-Atpdase 1Ecto-Atpase 1Ecto-ApyraseLymphoid Cell Activation AntigenNucleoside Triphosphate Diphosphohydrolase 1Ntpdase1Cd Antigen Cd39 |
Database Links | Reactome: R-HSA-8850843Reactome: R-HSA-9660826 |
Cellular Localisation | MembraneMulti-Pass Membrane ProteinCaveola |
Alternative Peptide Names | Ectonucleoside Triphosphate Diphosphohydrolase 1 proteinAtp Diphosphohydrolase proteinAtp-Dph proteinAtpdase proteinEcto-Atp Diphosphohydrolase 1 proteinEcto-Atpdase 1 proteinEcto-Atpase 1 proteinEcto-Apyrase proteinLymphoid Cell Activation Antigen proteinNucleoside Triphosphate Diphosphohydrolase 1 proteinNtpdase1 proteinCd Antigen Cd39 proteinENTPD1 proteinCD39 protein |
Information sourced from Uniprot.org