| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
BMP2 Blocking Peptide for STJ500274 is synthetically produced from the 45-60 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Bmp2 |
| Gene ID: |
12156 |
| Uniprot ID: |
BMP2_MOUSE |
| Immunogen Region: |
45-60 |
| Specificity: |
This blocking peptide is recommended for use in combination with BMP2 antibody, STJ500274 |
| Immunogen: |
Synthetic peptide corresponding to Mouse BMP2 amino acid region 45-60 conjugated to Keyhole Limpet Haemocyanin (KLH). Sequence: SEDVLSEFELRLLSMF |
| Function | Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling. |
| Peptide Name | Bone Morphogenetic Protein 2Bmp-2Bone Morphogenetic Protein 2aBmp-2a |
| Database Links | Reactome: R-MMU-201451Reactome: -MMU-2129379 |
| Cellular Localisation | Secreted |
| Alternative Peptide Names | Bone Morphogenetic Protein 2 proteinBmp-2 proteinBone Morphogenetic Protein 2a proteinBmp-2a proteinBmp2 proteinBmp-2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
