| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-AZI2-protein was developed from rabbit. For use in research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S4209RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AZI2 |
| Gene ID: |
64343 |
| Uniprot ID: |
AZI2_HUMAN |
| Immunogen Region: |
282-387 |
| Immunogen: |
Recombinant protein containing a sequence corresponding to amino acids 282-387 of human AZI2 (NP_071906.1). |
| Immunogen Sequence: |
YTRHPPLLPNGKALCHTTSS PLPGDVKVLSEKAILQSWTD NERSIPNDGTCFQEHSSYGR NSLEDNSWVFPSPPKSSETA FGETKTKTLPLPNLPPLHYL DQHNQN |
| Tissue Specificity | Widely expressed. Abundant expression seen in the pancreas and testis. |
| Post Translational Modifications | Ubiquitinated via 'Lys-48'-linked polyubiquitination by TRIM38, leading to its degradation. |
| Function | Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. |
| Protein Name | 5-Azacytidine-Induced Protein 2Nf-Kappa-B-Activating Kinase-Associated Protein 1Nak-Associated Protein 1Nap1Tilp |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | 5-Azacytidine-Induced Protein 2 proteinNf-Kappa-B-Activating Kinase-Associated Protein 1 proteinNak-Associated Protein 1 proteinNap1 proteinTilp proteinAZI2 proteinNAP1 proteinTBKBP2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
