| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | ASNA1 Blocking Peptide for STJ500178 is synthetically produced from the 300-348 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | GET3 |
| Gene ID: | 439 |
| Uniprot ID: | GET3_HUMAN |
| Immunogen Region: | 300-348 |
| Specificity: | This blocking peptide is recommended for use in combination with ASNA1 antibody, STJ500178 |
| Immunogen: | Synthetic peptide taken within amino acid region 300-348 on human ATPase ASNA1 protein. |
| Tissue Specificity | Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle. |
| Function | ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling. |
| Peptide Name | Atpase Get3 Arsenical Pump-Driving Atpase Arsenite-Stimulated Atpase Guided Entry Of Tail-Anchored Proteins Factor 3 - Atpase Transmembrane Domain Recognition Complex 40 Kda Atpase Subunit Harsa-I Hasna-I |
| Database Links | Reactome: R-HSA-9609523 |
| Cellular Localisation | Cytoplasm Endoplasmic Reticulum Nucleus Nucleolus |
| Alternative Peptide Names | Atpase Get3 protein Arsenical Pump-Driving Atpase protein Arsenite-Stimulated Atpase protein Guided Entry Of Tail-Anchored Proteins Factor 3 - Atpase protein Transmembrane Domain Recognition Complex 40 Kda Atpase Subunit protein Harsa-I protein Hasna-I protein GET3 protein ARSA protein ASNA1 protein TRC40 protein |
Information sourced from Uniprot.org