| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
ARHGEF7 Blocking Peptide for STJ500160 is synthetically produced from the 595-805 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
ARHGEF7 |
| Gene ID: |
8874 |
| Uniprot ID: |
ARHG7_HUMAN |
| Immunogen Region: |
595-805 |
| Specificity: |
This blocking peptide is recommended for use in combination with ARHGEF7 antibody, STJ500160 |
| Immunogen: |
Synthetic peptide taken within amino acid region 595-805 on human ARHGEF7 protein. |
| Post Translational Modifications | Phosphorylated by PTK2/FAK1.this promotes interaction with RAC1. Phosphorylated on Ser-694 by CaMK1.enhancement of GEF activity and downstream activation of RAC1. |
| Function | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. |
| Peptide Name | Rho Guanine Nucleotide Exchange Factor 7Beta-PixCool-1Pak-Interacting Exchange Factor BetaP85 |
| Database Links | Reactome: R-HSA-182971Reactome: R-HSA-193648Reactome: R-HSA-3928664Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013406Reactome: R-HSA-9013409Reactome: R-HSA-9013420Reactome: R-HSA-9013424Reactome: R-HSA-9619229 Q14155-1 |
| Cellular Localisation | Cell JunctionFocal AdhesionCell ProjectionRuffleCytoplasmCell CortexLamellipodiumDetected At Cell AdhesionsA Small Proportion Is Detected At Focal Adhesions |
| Alternative Peptide Names | Rho Guanine Nucleotide Exchange Factor 7 proteinBeta-Pix proteinCool-1 proteinPak-Interacting Exchange Factor Beta proteinP85 proteinARHGEF7 proteinCOOL1 proteinKIAA0142 proteinP85SPR proteinPAK3BP proteinPIXB proteinNbla10314 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
