| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Aquaporin 7 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Tissue Specificity | Detected in proximal tubules in kidney. Detected in the capillary network between muscle fibers in skeletal muscle and heart, and in spermatids and on spermatozoa tails in testis and epididymis. Detected in white and brown adipose tissue, especially on small blood vessels (at protein level). Detected in kidney and white adipose tissue. |
| Function | Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH. The channel is also permeable to urea. Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney. |
| Peptide Name | Aquaporin-7Aqp-7Aquaglyceroporin-7 |
| Database Links | Reactome: R-MMU-432030Reactome: -MMU-432047 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmCell CortexCytoplasmic Vesicle MembraneLipid DropletInternalized From The Cell Membrane In Response To Catecholamine-Induced Activation Of PkaDetected On Intracellular Membranes And Colocalizes With Lipid DropletsColocalizes With Plin1 In AdipocytesProbably On Lipid Droplets |
| Alternative Peptide Names | Aquaporin-7 proteinAqp-7 proteinAquaglyceroporin-7 proteinAqp7 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
