Aquaporin 11 Positive Control peptide (STJ503672)

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STJ503672-5

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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Aquaporin 11 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Aqp11
Gene ID: 286758
Uniprot ID: AQP11_RAT
Tissue Specificity Expressed in retina specifically at retinal Mueller glial cells. Expressed in adult testis, in the elongated spermatids (ES) and in residual bodies inside Sertoli cells.
Post Translational Modifications Not glycosylated.
Function Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway. Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER. Plays a role in the proximal tubule function by regulating its endosomal acidification. May play a role in postnatal kidney development.
Peptide Name Aquaporin-11
Aqp-11
Database Links Reactome: R-RNO-432047
Cellular Localisation Cytoplasmic Vesicle Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Cell Membrane
Cytoplasm
Perinuclear Region
Localizes Mainly To The Periphery Of Lipid Droplets
It Accumulates Partly In Mitochondrial-Associated Endoplasmic Reticulum Membranes
Alternative Peptide Names Aquaporin-11 protein
Aqp-11 protein
Aqp11 protein

Information sourced from Uniprot.org

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