| Function | Transcription factor that binds to cytidine clusters in double-stranded DNA. Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4. Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1. May also regulate alternative splicing of target genes during adipogenesis. |
| Protein Name | Zinc Finger Protein 638Cutaneous T-Cell Lymphoma-Associated Antigen Se33-1Ctcl-Associated Antigen Se33-1Nuclear Protein 220Zinc Finger Matrin-Like Protein |
| Database Links | Reactome: R-HSA-381340 |
| Cellular Localisation | Nucleus Speckle |
| Alternative Antibody Names | Anti-Zinc Finger Protein 638 antibodyAnti-Cutaneous T-Cell Lymphoma-Associated Antigen Se33-1 antibodyAnti-Ctcl-Associated Antigen Se33-1 antibodyAnti-Nuclear Protein 220 antibodyAnti-Zinc Finger Matrin-Like Protein antibodyAnti-ZNF638 antibodyAnti-NP220 antibodyAnti-ZFML antibody |
Information sourced from Uniprot.org
