| Post Translational Modifications | Ubiquitinated upon prolonged exposure to genotoxic stress, which leads to proteasomal degradation of ZNF385A and releases p53/TP53 from cell-cycle arrest target gene promoters. |
| Function | RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. |
| Protein Name | Zinc Finger Protein 385aHematopoietic Zinc Finger ProteinRetinal Zinc Finger Protein |
| Database Links | Reactome: R-HSA-6804114Reactome: R-HSA-6804116Reactome: R-HSA-6804759Reactome: R-HSA-69895 |
| Cellular Localisation | CytoplasmNucleusNucleolusCell ProjectionDendriteDetected In Dendrites Of Purkinje Cells And Hippocampal Neurons |
| Alternative Antibody Names | Anti-Zinc Finger Protein 385a antibodyAnti-Hematopoietic Zinc Finger Protein antibodyAnti-Retinal Zinc Finger Protein antibodyAnti-ZNF385A antibodyAnti-HZF antibodyAnti-RZF antibodyAnti-ZNF385 antibody |
Information sourced from Uniprot.org
