| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZFYVE27 (217-411) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZFYVE27 |
| Gene ID: |
118813 |
| Uniprot ID: |
ZFY27_HUMAN |
| Immunogen Region: |
217-411 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 217-411 of human ZFYVE27 (NP_653189.3). |
| Immunogen Sequence: |
VEFFRVVSEYRASLQQRMNP KQEEHAFESPPPPDVGGKDG LMDSTPALTPTEDLTPGSVE EAEEAEPDEEFKDAIEETHL VVLEDDEGAPCPAEDELALQ DNGFLSKNEVLRSKVSRLTE RLRKRYPTNNFGNCTGCSAT FSVLKKRRSCSNCGNSFCSR CCSFKVPKSSMGATAPEAQR ETVFVCASCNQTLSK |
| Post Translational Modifications | Phosphorylated. Phosphorylation is induced by NGF through the MAPK/ERK pathway and modulates interaction with RAB11A. |
| Function | Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner. |
| Protein Name | ProtrudinSpastic Paraplegia 33 ProteinZinc Finger Fyve Domain-Containing Protein 27 |
| Cellular Localisation | Recycling Endosome MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneCell ProjectionGrowth Cone MembraneLocalizes At Both Dendrites And AxonsLocalizes To Endoplasmic Reticulum Tubular Network |
| Alternative Antibody Names | Anti-Protrudin antibodyAnti-Spastic Paraplegia 33 Protein antibodyAnti-Zinc Finger Fyve Domain-Containing Protein 27 antibodyAnti-ZFYVE27 antibodyAnti-SPG33 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
