| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-XPOT (1-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
XPOT |
| Gene ID: |
11260 |
| Uniprot ID: |
XPOT_HUMAN |
| Immunogen Region: |
1-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human XPOT (NP_009166.2). |
| Immunogen Sequence: |
MDEQALLGLNPNADSDFRQR ALAYFEQLKISPDAWQVCAE ALAQRTYSDDHVKFFCFQVL EHQVKYKYSELTTVQQQLIR ETLISWLQAQMLNPQPEKTF IRNKAAQVFALLFVTEYLTK WPKFFFDILSVVDLNPRGVD LYLRILMAIDSELVDRDVVH TSEEARRNTLIKDTMREQCI PNLVESWYQILQNYQFTNSE |
| Function | Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| Protein Name | Exportin-TExportin(TrnaTrna Exportin |
| Database Links | Reactome: R-HSA-6784531 |
| Cellular Localisation | NucleusCytoplasmNuclearOnce Bound To Trna And Ran The Complex Translocates To The CytoplasmShuttles Between The Nucleus And The Cytoplasm |
| Alternative Antibody Names | Anti-Exportin-T antibodyAnti-Exportin(Trna antibodyAnti-Trna Exportin antibodyAnti-XPOT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
