| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | XPO1 |
| Gene ID: | 7514 |
| Uniprot ID: | XPO1_HUMAN |
| Immunogen Region: | 964-1064 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 964-1064 of human CRM1/CRM1/XPO1 (NP_003391.1). |
| Immunogen Sequence: | PGNPVNNQIFLQEYVANLLK SAFPHLQDAQVKLFVTGLFS LNQDIPAFKEHLRDFLVQIK EFAGEDTSDLFLEEREIALR QADEEKHKRQMSVPGIFNPH E |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney. |
| Function | Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. |
| Protein Name | Exportin-1 Exp1 Chromosome Region Maintenance 1 Protein Homolog |
| Database Links | Reactome: R-HSA-141444 Reactome: R-HSA-165054 Reactome: R-HSA-168333 Reactome: R-HSA-2173788 Reactome: R-HSA-2467813 Reactome: R-HSA-2500257 Reactome: R-HSA-3769402 Reactome: R-HSA-450520 Reactome: R-HSA-5663220 Reactome: R-HSA-5687128 Reactome: R-HSA-68877 Reactome: R-HSA-69273 Reactome: R-HSA-9634638 Reactome: R-HSA-9648025 Reactome: R-HSA-9707616 Reactome: R-HSA-9768919 Reactome: R-HSA-9828806 Reactome: R-HSA-9856649 |
| Cellular Localisation | Cytoplasm Nucleus Nucleoplasm Cajal Body Nucleolus Located In The Nucleoplasm Cajal Bodies And Nucleoli Shuttles Between The Nucleus/Nucleolus And The Cytoplasm |
| Alternative Antibody Names | Anti-Exportin-1 antibody Anti-Exp1 antibody Anti-Chromosome Region Maintenance 1 Protein Homolog antibody Anti-XPO1 antibody Anti-CRM1 antibody |
Information sourced from Uniprot.org