| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | WRNIP1 |
| Gene ID: | 56897 |
| Uniprot ID: | WRIP1_HUMAN |
| Immunogen Region: | 401-640 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 401-640 of human WRNIP1 (NP_569079.1). |
| Immunogen Sequence: | DKAVDTLAYLSDGDARAGLN GLQLAVLARLSSRKMFCKKS GQSYSPSRVLITENDVKEGL QRSHILYDRAGEEHYNCISA LHKSMRGSDQNASLYWLARM LEGGEDPLYVARRLVRFASE DIGLADPSALTQAVAAYQGC HFIGMPECEVLLAQCVVYFA RAPKSIEVYSAYNNVKACLR NHQGPLPPVPLHLRNAPTRL MKDLGYGKGYKYNPMYSEPV DQEYLPEELRGVDFFKQRR |
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Sumoylated with SUMO1 and SUMO2/3. |
| Function | Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. |
| Protein Name | Atpase Wrnip1Werner Helicase-Interacting Protein 1 |
| Cellular Localisation | NucleusCytoplasmColocalizes With Wrn In Granular Structures In The Nucleus |
| Alternative Antibody Names | Anti-Atpase Wrnip1 antibodyAnti-Werner Helicase-Interacting Protein 1 antibodyAnti-WRNIP1 antibodyAnti-WHIP antibody |
Information sourced from Uniprot.org