| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WRNIP1 (401-640) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WRNIP1 |
| Gene ID: |
56897 |
| Uniprot ID: |
WRIP1_HUMAN |
| Immunogen Region: |
401-640 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 401-640 of human WRNIP1 (NP_569079.1). |
| Immunogen Sequence: |
DKAVDTLAYLSDGDARAGLN GLQLAVLARLSSRKMFCKKS GQSYSPSRVLITENDVKEGL QRSHILYDRAGEEHYNCISA LHKSMRGSDQNASLYWLARM LEGGEDPLYVARRLVRFASE DIGLADPSALTQAVAAYQGC HFIGMPECEVLLAQCVVYFA RAPKSIEVYSAYNNVKACLR NHQGPLPPVPLHLRNAPTRL MKDLGYGKGYKYNPMYSEPV DQEYLPEELRGVDFFKQRR |
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Sumoylated with SUMO1 and SUMO2/3. |
| Function | Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. |
| Protein Name | Atpase Wrnip1Werner Helicase-Interacting Protein 1 |
| Cellular Localisation | NucleusCytoplasmColocalizes With Wrn In Granular Structures In The Nucleus |
| Alternative Antibody Names | Anti-Atpase Wrnip1 antibodyAnti-Werner Helicase-Interacting Protein 1 antibodyAnti-WRNIP1 antibodyAnti-WHIP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
