Tissue Specificity | Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain. |
Post Translational Modifications | Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. |
Function | Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin. |
Protein Name | Protein Wnt-10bProtein Wnt-12 |
Database Links | Reactome: R-HSA-3238698Reactome: R-HSA-373080Reactome: R-HSA-381340 |
Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
Alternative Antibody Names | Anti-Protein Wnt-10b antibodyAnti-Protein Wnt-12 antibodyAnti-WNT10B antibodyAnti-WNT12 antibody |
Information sourced from Uniprot.org