| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WDR26 (362-661) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WDR26 |
| Gene ID: |
80232 |
| Uniprot ID: |
WDR26_HUMAN |
| Immunogen Region: |
362-661 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 362-661 of human WDR26 (NP_079436.4). |
| Immunogen Sequence: |
KFSNDGTKLATGSKDTTVII WQVDPDTHLLKLLKTLEGHA YGVSYIAWSPDDNYLVACGP DDCSELWLWNVQTGELRTKM SQSHEDSLTSVAWNPDGKRF VTGGQRGQFYQCDLDGNLLD SWEGVRVQCLWCLSDGKTVL ASDTHQRIRGYNFEDLTDRN IVQEDHPIMSFTISKNGRLA LLNVATQGVHLWDLQDRVLV RKYQGVTQGFYTIHSCFGGH NEDFIASGSEDHKVYIWHK |
| Tissue Specificity | Broadly expressed, with highest levels in heart and skeletal muscle. |
| Function | G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria. Protects also cells by promoting hypoxia-mediated autophagy and mitophagy. |
| Protein Name | Wd Repeat-Containing Protein 26Cul4- And Ddb1-Associated Wdr Protein 2Myocardial Ischemic Preconditioning Up-Regulated Protein 2 |
| Cellular Localisation | CytoplasmNucleusMitochondrion |
| Alternative Antibody Names | Anti-Wd Repeat-Containing Protein 26 antibodyAnti-Cul4- And Ddb1-Associated Wdr Protein 2 antibodyAnti-Myocardial Ischemic Preconditioning Up-Regulated Protein 2 antibodyAnti-WDR26 antibodyAnti-CDW2 antibodyAnti-MIP2 antibodyAnti-PRO0852 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
