| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WDFY2 (1-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WDFY2 |
| Gene ID: |
115825 |
| Uniprot ID: |
WDFY2_HUMAN |
| Immunogen Region: |
1-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human WDFY2 (NP_443182.1). |
| Immunogen Sequence: |
MAAEIQPKPLTRKPILLQRM EGSQEVVNMAVIVPKEEGVI SVSEDRTVRVWLKRDSGQYW PSVYHAMPSPCSCMSFNPET RRLSIGLDNGTISEFILSED YNKMTPVKNYQAHQSRVTMI LFVLELEWVLSTGQDKQFAW HCSESGQRLGGYRTSAVASG LQFDVETRHVFIGDHSGQVT ILKLEQENCTLVTTFRGHTG |
| Function | Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1. Plays a role in endosomal control of AKT2 signaling.required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates. Participates in transferrin receptor endocytosis. |
| Protein Name | Wd Repeat And Fyve Domain-Containing Protein 2Propeller-Fyve ProteinProfWd40- And Fyve Domain-Containing Protein 2Zinc Finger Fyve Domain-Containing Protein 22 |
| Cellular Localisation | EndosomeEarly EndosomeCytoplasmLocalizes To Intracellular VesiclesColocalizes With Vamp2 And Prkcz In Intracellular VesiclesColocalizes With Akt2 In Early Endosomes |
| Alternative Antibody Names | Anti-Wd Repeat And Fyve Domain-Containing Protein 2 antibodyAnti-Propeller-Fyve Protein antibodyAnti-Prof antibodyAnti-Wd40- And Fyve Domain-Containing Protein 2 antibodyAnti-Zinc Finger Fyve Domain-Containing Protein 22 antibodyAnti-WDFY2 antibodyAnti-WDF2 antibodyAnti-ZFYVE22 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
