| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-VCPIP1 (923-1222) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
VCPIP1 |
| Gene ID: |
80124 |
| Uniprot ID: |
VCIP1_HUMAN |
| Immunogen Region: |
923-1222 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 923-1222 of human VCPIP1 (NP_079330.2). |
| Immunogen Sequence: |
VFYSIMKKTMGMADGKHCTF PHLPGKTFVYNASEDRLELC VDAAGHFPIGPDVEDLVKEA VSQVRAEATTRSRESSPSHG LLKLGSGGVVKKKSEQLHNV TAFQGKGHSLGTASGNPHLD PRARETSVVRKHNTGTDFSN SSTKTEPSVFTASSSNSELI RIAPGVVTMRDGRQLDPDLV EAQRKKLQEMVSSIQASMDR HLRDQSTEQSPSDLPQRKTE VVSSSAKSGSLQTGLPESF |
| Post Translational Modifications | Phosphorylated at Ser-1207 by ATM or ATR following induction of covalent DNA-protein cross-links (DPCs). |
| Function | Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains. (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. |
| Protein Name | Deubiquitinating Protein Vcpip1Valosin-Containing Protein P97/P47 Complex-Interacting Protein 1Valosin-Containing Protein P97/P47 Complex-Interacting Protein P135Vcp/P47 Complex-Interacting 135-Kda Protein |
| Database Links | Reactome: R-HSA-5689896 |
| Cellular Localisation | NucleusCytoplasmEndoplasmic ReticulumGolgi ApparatusGolgi StackAssociated With Golgi Stacks And Endoplasmic ReticulumDisplays Cytoplasmic To Nuclear Translocation In Response To Dna-Protein Cross-Links (Dpcs)-Inducing Agents |
| Alternative Antibody Names | Anti-Deubiquitinating Protein Vcpip1 antibodyAnti-Valosin-Containing Protein P97/P47 Complex-Interacting Protein 1 antibodyAnti-Valosin-Containing Protein P97/P47 Complex-Interacting Protein P135 antibodyAnti-Vcp/P47 Complex-Interacting 135-Kda Protein antibodyAnti-VCPIP1 antibodyAnti-KIAA1850 antibodyAnti-VCIP135 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
