| Tissue Specificity | Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions. |
| Post Translational Modifications | 2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa) may be processed by proteolytic cleavage. The largest form (42 kDa) seems to be secreted and the other major form (63 kDa) seems to accumulate within the cells or pericellular milieu. Polypeptide consisting of Met-77 to Arg-318 may correspond to the 27 kDa form and that consisting of Met-77 to Val-365 may correspond to the 36 kDa form. Ubiquitinated in vitro. |
| Function | Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning. Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. |
| Protein Name | Tubulinyl-Tyr Carboxypeptidase 1Tubulin Carboxypeptidase 1Tyrosine Carboxypeptidase 1Ttcp 1Vasohibin-1 |
| Database Links | Reactome: R-HSA-8955332 |
| Cellular Localisation | CytoplasmSecretedMainly Localizes In The CytoplasmSome Fraction Is Secreted Via A Non-Canonical Secretion SystemInteraction With Svbp Promotes Secretion |
| Alternative Antibody Names | Anti-Tubulinyl-Tyr Carboxypeptidase 1 antibodyAnti-Tubulin Carboxypeptidase 1 antibodyAnti-Tyrosine Carboxypeptidase 1 antibodyAnti-Ttcp 1 antibodyAnti-Vasohibin-1 antibodyAnti-VASH1 antibodyAnti-KIAA1036 antibodyAnti-VASH antibody |
Information sourced from Uniprot.org
