| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-USP19 (1-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
USP19 |
| Gene ID: |
10869 |
| Uniprot ID: |
UBP19_HUMAN |
| Immunogen Region: |
1-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human USP19 (NP_001186089.1). |
| Immunogen Sequence: |
MSGGASATGPRRGPPGLEDT TSKKKQKDRANQESKDGDPR KETGSRYVAQAGLEPLASGD PSASASHAAGITGSRHRTRL FFPSSSGSASTPQEEQTKEG ACEDPHDLLATPTPELLLDW RQSAEEVIVKLRVGVGPLQL EDVDAAFTDTDCVVRFAGGQ QWGGVFYAEIKSSCAKVQTR KGSLLHLTLPKKVPMLTWPS |
| Function | Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 19Deubiquitinating Enzyme 19Ubiquitin Thioesterase 19Ubiquitin-Specific-Processing Protease 19Zinc Finger Mynd Domain-Containing Protein 9 |
| Database Links | Reactome: R-HSA-5689880 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 19 antibodyAnti-Deubiquitinating Enzyme 19 antibodyAnti-Ubiquitin Thioesterase 19 antibodyAnti-Ubiquitin-Specific-Processing Protease 19 antibodyAnti-Zinc Finger Mynd Domain-Containing Protein 9 antibodyAnti-USP19 antibodyAnti-KIAA0891 antibodyAnti-ZMYND9 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
