| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ULK3 (44-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ULK3 |
| Gene ID: |
25989 |
| Uniprot ID: |
ULK3_HUMAN |
| Immunogen Region: |
44-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 44-240 of human ULK3 (NP_001092906.3). |
| Immunogen Sequence: |
KCVAKKSLNKASVENLLTEI EILKGIRHPHIVQLKDFQWD SDNIYLIMEFCAGGDLSRFI HTRRILPEKVARVFMQQLAS ALQFLHERNISHLDLKPQNI LLSSLEKPHLKLADFGFAQH MSPWDEKHVLRGSPLYMAPE MVCQRQYDARVDLWSMGVIL YEALFGQPPFASRSFSELEE KIRSNRVIELPLRPLLS |
| Tissue Specificity | Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord. |
| Post Translational Modifications | Autophosphorylated. Autophosphorylation is blocked by interaction with SUFU. |
| Function | Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. |
| Protein Name | Serine/Threonine-Protein Kinase Ulk3Unc-51-Like Kinase 3 |
| Database Links | Reactome: R-HSA-5632684 |
| Cellular Localisation | CytoplasmLocalizes To Pre-Autophagosomal Structure During Cellular Senescence |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Ulk3 antibodyAnti-Unc-51-Like Kinase 3 antibodyAnti-ULK3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
