| Tissue Specificity | Expressed in many tissues. Present in liver, prostate and testis. |
| Function | UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens). Displays glucuronidation activity toward several classes of xenobiotic substrates, including phenolic compounds (eugenol, 4-nitrophenol, 4-hydroxybiphenyl) and phenylpropanoids (naringenin, coumarins). Catalyzes the glucuronidation of monoterpenoid alcohols such as borneol, menthol and isomenthol, a class of natural compounds used in essential oils. |
| Protein Name | Udp-Glucuronosyltransferase 2b15Udpgt 2b15Ugt2b15Hlug4Udp-Glucuronosyltransferase 2b8Udpgt 2b8Udpgth-3 |
| Database Links | Reactome: R-HSA-156588Reactome: R-HSA-9749641Reactome: R-HSA-9753281 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Udp-Glucuronosyltransferase 2b15 antibodyAnti-Udpgt 2b15 antibodyAnti-Ugt2b15 antibodyAnti-Hlug4 antibodyAnti-Udp-Glucuronosyltransferase 2b8 antibodyAnti-Udpgt 2b8 antibodyAnti-Udpgth-3 antibodyAnti-UGT2B15 antibodyAnti-UGT2B8 antibody |
Information sourced from Uniprot.org
