| Tissue Specificity | Isoform 1: Expressed in liver, kidney, colon, esophagus and small intestine. Isoform 2: Expressed in liver, kidney, colon, esophagus and small intestine. |
| Function | Isoform 1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan. Also metabolizes mycophenolate, an immunosuppressive agent. Isoform 2: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. |
| Protein Name | Udp-Glucuronosyltransferase 1a9Ugt1a9Udp-Glucuronosyltransferase 1-9Udpgt 1-9Ugt1*9Ugt1-09Ugt1.9Udp-Glucuronosyltransferase 1-IUgt-1iUgt1iLugp4 |
| Database Links | Reactome: R-HSA-156588Reactome: R-HSA-1989781Reactome: R-HSA-9749641Reactome: R-HSA-9753281 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Udp-Glucuronosyltransferase 1a9 antibodyAnti-Ugt1a9 antibodyAnti-Udp-Glucuronosyltransferase 1-9 antibodyAnti-Udpgt 1-9 antibodyAnti-Ugt1*9 antibodyAnti-Ugt1-09 antibodyAnti-Ugt1.9 antibodyAnti-Udp-Glucuronosyltransferase 1-I antibodyAnti-Ugt-1i antibodyAnti-Ugt1i antibodyAnti-Lugp4 antibodyAnti-UGT1A9 antibodyAnti-GNT1 antibodyAnti-UGT1 antibody |
Information sourced from Uniprot.org
