| Tissue Specificity | Expressed in skin. Isoforms 1 and 3 are expressed in kidney and liver. Isoform 1 but not isoform 2 is expressed in colon, esophagus and small intestine. |
| Function | Isoform 1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to facilitate their inactivation and excretion from the body. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE and 20-HETE. Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate. Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group. Isoform 3: Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1. |
| Protein Name | Udp-Glucuronosyltransferase 1a6Ugt1a6Phenol-Metabolizing Udp-GlucuronosyltransferaseUdp-Glucuronosyltransferase 1-6Udpgt 1-6Ugt1*6Ugt1-06Ugt1.6Udp-Glucuronosyltransferase 1-FUgt-1fUgt1f |
| Database Links | Reactome: R-HSA-156588Reactome: R-HSA-9749641Reactome: R-HSA-9753281 |
| Cellular Localisation | MicrosomeEndoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Udp-Glucuronosyltransferase 1a6 antibodyAnti-Ugt1a6 antibodyAnti-Phenol-Metabolizing Udp-Glucuronosyltransferase antibodyAnti-Udp-Glucuronosyltransferase 1-6 antibodyAnti-Udpgt 1-6 antibodyAnti-Ugt1*6 antibodyAnti-Ugt1-06 antibodyAnti-Ugt1.6 antibodyAnti-Udp-Glucuronosyltransferase 1-F antibodyAnti-Ugt-1f antibodyAnti-Ugt1f antibodyAnti-UGT1A6 antibodyAnti-GNT1 antibodyAnti-UGT1 antibody |
Information sourced from Uniprot.org
